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Furthermore, in vitro analysis has shown that for example breast cancer cells exhibit increased proliferation and migration in the presence of HDL [70]

Additionally, their specificity remains a concern as they could inhibit other HDAC isoforms leading to unwanted side effects 65,66

A number of natural products, such as triterpenoid saponins (Xu et al., 2018), schisandra lignans (Zhu et al., 2019), polysaccharides (Wang et al., 2018), iridoids (Shao et al., 2017), flavonoids and quinones ( 2 Effects and mechanism of natural products in acetaminophen-induced hepatotoxicity A number of phytochemicals have been identified to have hepatoprotective activity, such as silymarin for the treatment of liver poisoning, chronic hepatitis and cirrhosis (McGill et al., 2015